Nootropics Anabolic Steroid Powder Vinpocetine for Cerebrovascular Expansion CAS 42971-09-5
Nootropics Anabolic Steroid Powder Vinpocetine for Cerebrovascular Expansion CAS 42971-09-5
Categories Anabolic Steroid Powder Brand Name: Excellentbiotech Model Number: 42971-09-5 Certification: ISO9001 Place of Origin: China MOQ: 10g Price: USD1-10/g Payment Terms: T/T, , ,Bitcoin Supply Ability: 5000kg Delivery Time: 5-8 works day Packaging Details: stealth package Color: White Appearance: Powder Product Name: Vinpocetine Assay: 99% Usage: Cerebrovascular Expansion Contact Now
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Product name: Vinpocetine
Other Name: Eburnamenine-14-carboxylic acid ethylester;(3α,16α)-Eburnamenine-14-carboxylic acid ethyl ester
Plant Origin: voacanga seed extract
Specification: 99%
CAS NO. : 42971-09-5
Molecular weight: 350.45
Molecular formula: C22H26N2O2
Appearance: light yellow to off-white powder
Description:Vinpocetine is a derivative of Vincamine, which is extracted fromthe Periwinkle plant ( Vinca Minor, Vinca Pervinca ). Researchsuggests that Vinpocetine helps to maintain healthy bloodcirculation in the brain and supports certain neurotransmitters inthe memory process. Vinpocetine supports and protects brain bloodvessel health and aids mental function.
(1) Vinpocetine is a cerebrovascular expansion drug and has arelatively stronger function than Vincamine. It can selectivelyincrease cerebral blood flow, enhance and improve brain oxygensupply, promote metabolism, enhance the capacity of deformation forred blood cells, reduce blood viscosity, inhibit plateletaggregation, improve tissue metabolism.(2) Vinpocetine is mainly used in the treatment of cerebralinfarction sequela, cerebral hemorrhage sequelae, cerebralarteriosclerosis, etc. It can also used in the treatment of retinalvascular sclerosis and blood vessel spasm, the elderly deafness,and dizziness.(3) Vinpocetine is a half synthetic Vincamine derivative, and hasthe similar effect with Vincamine. It has a stronger expansionfunction for cerebrovascular selectively.
Pharmacological effects are as follows:Inhibit the activity of calcium dependency phosphodiesterase,increase the content of cAMP which can relax vascular smoothmuscle, then relax vascular smooth muscle, and further increasecerebral blood flow. Enhance the capacity of deformation of redblood cells, reduce blood viscosity, inhibit platelet aggregation,and thus improve blood flow and microcirculation. Promote the braintissue to absorb glucose, and promote the transformation of brainmonoamine metabolism. Inhibit the increase of brain lactic acidduring cerebral ischemia, increase the ATP content, inhibit thegeneration of lipid peroxide in the brain, delay the occurring ofspasm caused by cerebral ischemia, have the function of improvingcerebral metabolism and protecting brain.
Application:1)VINPOCETINE is a semisynthetic derivative alkaloid of vincamine,and also can be semisynthesized from tabersonine, an extract fromVoacanga Africana Seed.2)Clinical studies suggest that it facilitates cerebral metabolismby improving cerebral blood flow, increasing glucose and oxygenutilization by neurons and concentration of neurotransmittersinvolved in the process of memory formation.3)Clinical studies have also shown that Vinpocetine may help tomaintain healthy microcirculation in the inner vital organs of earsand eyes.4)Research has shown that the effects of this compound go beyondmere prevention and turn it into a Powerful Memory Enhancer.
1. It has vasodilating, blood thinning, and memory-enhancingactions.2. It acts as a cerebral stimulant and vasodilator.3. It is used to treat arteriosclerosis.4. It is very effective in curing dementia caused due toinsufficient blood supply to the brain.5. It interferes with cells' ability to synthesize DNA and RNA.
Vinpocetine is a kind of natural medicine extracted from smallvinca flower, and belongs to the indole alkaloids. Can be syntheticnow. The mechanism of its pharmacological action is to inhibit theactivity of calcium dependency phosphodiesterase, increase thecontent of CGMP which can relax vascular smooth muscle, then relaxvascular smooth muscle, and further increase cerebral blood flow;Enhance the capacity of deformation of red blood cells, reduceblood viscosity, inhibit platelet aggregation, and thus improveblood flow and microcirculation; Promote the brain tissue to absorbglucose, and promote the transformation of brain monoaminemetabolism; Inhibit the increase of brain lactic acid duringcerebral ischemia, increase the ATP content, increase thedegree ofoxygen dissociation in hemoglobin; Increase the resistance capacityfor cerebral anoxia and occurring of spasm caused by cerebralischemia, inhibit the generation of lipid peroxide in the brain.Oral absorption effectively, reach peak at 1 h, then metabolizeinto Vinpocetine in the body. The half-life of plasma eliminationis about 1 hour. For 4 weeks in a row, no accumulation in the body.Clinical used in cerebral infarction sequela, cerebral hemorrhagesequelae, cerebral arteriosclerosis, cerebral vasospasm, brainendarteritis caused vertigo, tinnitus, headache, dizziness, limbnumbness, incontinence and other clinical manifestations,depression, anxiety, sleep disorder and other mental symptoms.Clinical experience has shown that it is effective regardless ofthe length of the course of the disease, and the symptom is fixedor not.
Recommend Dosage :
Take Vinpocetine with meals to enhance absorption.
The standard low dose is 5mg of Vinpocetine at each of these threemeals, with 20mg per meal seen as a high dose. This dose range issuitable for the purposes of neuroprotection, enhancing cerebralblood flow, and reducing the rate of cognitive decline.
Side EffectsIV administration of Vinpocetine can cause serious adverse effects,such as death from sudden falls in blood pressure and heart rate(R, R2). However, this is not an issue with oral Vinpocetine at thestandard dosages.
There have been reports of skin allergy to vincamine (R).
There was also one report of a sudden drop in white blood cellcount at 15mg per day (R).
COA of the Vinpocetine:
ItemsSpecification
ResultsappearanceWhite or slightly yellow, crystalline powderWhite crystallineSolubilityPractically insoluble in water, soluble in methylene chloride,slightly soluble in anhydrousethanolconfirmsIdentification (IR)same wave numbers as that of the Vinpocetine, CRS similarlyprepared
CRS similarly prepared.
ConformsSpecific Optical Rotation(On dried basis)Between +127° and +134°+132.7°Related Substances (External Standard method)Ethyl vincaminate(A)≤0.6%ConformsApovincamine(B)≤0.5%ConformsMethoxyvinpocetine(C)≤0.3%Not detectedDihydrovinpocetine(D)≤ 0.5%Not detectedOther single impurity≤0.10%ConformsTotal impurity≤ 1.0%0.19%Loss on drying
≤ 0.5%0.04%Sulphated ash
≤ 0.1%0.07%Assay(On dried basis)98.5% ~101,5% ,100.2%
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Nootropics Anabolic Steroid Powder Vinpocetine for Cerebrovascular Expansion CAS 42971-09-5
Suzhou Excellentbiotech Co.,Ltd
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